HPLC Method for Determination of Hydroxyzine in Tablets on Primesep SB Column

HPLC-Applikation • Datum: 2018/11/27
HPLC Method for Determination of Hydroxyzine in Tablets on Primesep SB Column Chromatogramm

Hydroxyzine is an antihistamine medication that is used to treat various conditions.

Antihistamine: Hydroxyzine belongs to the class of drugs known as first-generation antihistamines. It works by blocking the effects of histamine, a natural substance in the body that is involved in allergic reactions.

Uses: Hydroxyzine is used to treat itching caused by allergies, as well as to relieve symptoms of allergic reactions such as hives. It is also used as a sedative to manage anxiety and tension.

Allergic Reactions: In the context of allergic reactions, hydroxyzine helps alleviate symptoms like itching, redness, and swelling by blocking histamine receptors.

Anxiolytic Properties: It has sedative and anxiolytic (anxiety-reducing) properties, and it is sometimes prescribed to manage anxiety and tension.

Forms: Hydroxyzine is available in various forms, including tablets, capsules, and oral solutions. It can also be administered by injection in certain medical situations.

Methodenparameter

ColumnPrimesep SB, 4.6 x 150 mm, 5 µm, 100 Å, dual ended
Mobile PhaseMeCN/H2O – 20/80%
BufferH2SO4 – 0.1%
Flow Rate1.0 mL/min
DetectionUV, 232 nm