HPLC Determination of Benzoic Anhydride on Newcrom R1 Column
High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzoic Anhydride.
Benzoic Anhydride is the more active analogue of benzoic acid formed via dehydration. It has the chemical formula C14H10O3 . Benzoic anhydride is used as a benzoylating agent in the manufacture of pharmaceuticals, intermediates and dyes. It is considered the simplest symmetrical aromatic acid anhydride.
Benzoic Anhydride can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN), water and detected by UV, ELSD, CAD or LC/MS.
Methodenparameter
| Column | Newcrom R1, 4.6 x 150 mm, 5 µm, 100 Å, dual ended |
|---|---|
| Mobile Phase | MeCN – 70% |
| Buffer | No |
| Flow Rate | 1.0 mL/min |
| Detection | UV 275 nm |