HPLC Method For Analysis Of Ubrogepant in UBRELVY® Tablets on Newcrom R1 Column

Ubrogepant, also known as Ubrelvy®, is a newly discovered, calcitonin gene-related peptide receptor (CGPR) antagonist that is used for the acute treatment of migraine headaches. Ubrogepant can be retained and analyzed on a Newcrom R1 mixed-mode column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and no buffer. This analysis method can be UV detected at 285 nm with high resolution and peak symmetry.

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A , AH , B , and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.