HPLC Method for Analysis of Quetiapine in Tablets on Newcrom R1 Column
High Performance Liquid Chromatography (HPLC) Method for Analysis of Quetiapine
Quetiapine is an antipsychotic medication with the molecular formula of C21H25N3O2S • 1/2C 4 H4 O4 . It is only available through prescription to treat a variety of mental health disorders. It blocks neurotransmitters in the brain, and by altering levels of the chemicals produced, it can help regulate behavior.
Quetiapine can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a Triethanolamine buffer. Detection is performed using UV.
Methodenparameter
| Column | Newcrom R1, 4.6 x 100 mm, 5 µm, 100 Å, dual ended |
|---|---|
| Mobile Phase | MeCN/H2O – 20/80% |
| Buffer | TEAPh – 50 mM |
| Flow Rate | 1.0 mL/min |
| Detection | UV, 250 nm |