HPLC MS Method for Analysis of Evogliptin and Mannitol in Pharmaceutical Dosage Form on Primesep 200 Column

Evogliptin is a drug that belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. It is used primarily for the treatment of type 2 diabetes mellitus. DPP-4 inhibitors work by blocking the action of the enzyme DPP-4, which in turn increases the levels of incretin hormones such as GLP-1 (glucagon-like peptide-1). This increase helps to stimulate insulin release and suppress glucagon secretion, thereby helping to regulate blood sugar levels in patients with diabetes.

Evogliptin can be retained, and analyzed using a Primesep 200 mixed-mode stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and Ammomium Formate as a buffer. Detection is achieved using UV at 265 nm

You can find detailed UV spectra of Evogliptin and information about its various lambda maxima by visiting the following link .