HPLC Method for Analysis of 2-Chlorobenzyl Chloride and 4-Chlorobenzyl Chloride on Newcrom R1 Column
High Performance Liquid Chromatography (HPLC) Method for Analysis of 2-Chlorobenzyl chloride , 4-Chlorobenzyl chloride
2-Chlorobenzyl Chloride Pharmaceutical intermediate – used to build drugs with chlorinated aromatic structures.
Agrochemicals – precursor for pesticides and herbicides.
Organic synthesis – for introducing a 2-chlorobenzyl group via nucleophilic substitution.
Dyes and pigments – used in manufacturing colorants.
4-Chlorobenzyl Chloride Pharmaceuticals – key building block for antihistamines, antidepressants, etc.
Methodenparameter
| Column | Newcrom R1, 3.2 x 100 mm, 5 µm, 100 Å, dual ended |
|---|---|
| Mobile Phase | MeCN -45% |
| Buffer | H3PO4 – 0.1% |
| Flow Rate | 1.0 mL/min |
| Detection | UV 210 nm |
| Limit of Detection | 6.8 ppb, 9.9 ppb |