HPLC Separation of Drugs in Tylenol Cold and Cough Remedies
https://sielc.com/Application-HPLC-Separation-of-Drugs-in-Tylenol-Cold-and-Cough-RemediesChromatogram
Description
Components of Tylenol Cold and Cough Remedy are separated on Obelisc R mixed-mode column. Method can be used to determine compounds in various cough and cold compositions. Neutral (acetaminophen), basic (chlorpheniramine, dextromethorphan and pseudoephedrine) and acidic (maleic acid/Maleate) components are analyzed with perfect peak shape and retention control. Method can be used in production, QC/QA and biological studies for quantitation of various components in pharmaceutical formulations (Advil, Tylenol, Dimetapp, Robitussin, NyQuil, etc)
Method Parameters
| Mobile Phase | MeCN |
|---|---|
| Buffer | AmFm |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds | Drug, Analgetic, Acid, Hydrophilic, Ionizable, Neutral, Basic |
| Analyzing Compounds | Maleate, Chlorpheniramine, Dextromethorphan, Pseudoephedrine, Acetaminophen |
HPLC Column Used
Obelisc R, 4.6×150 mm, 5 µm, 100A