HPLC Method for Analysis of Trimellitic Anhydride and Trimellitic Acid on Newcrom B Column

High Performance Liquid Chromatography (HPLC) Method for Analysis of Trimellitic anhydride , Trimellitic Acid .

Trimellitic anhydride is a trifunctional, highly reactive aromatic anhydride with the chemical formula C9H4O5 . It is used as a curing agent for epoxy and other resins; in vinyl plasticizers, paints, coatings, dyes, pigments and a wide variety of other manufactured products. It is a common precursor to plasticizers for polyvinyl chloride (PVC). In acidic water, Trimellitic Anhydride will ‘open up’ back into Trimellitic Acid .

Trimellitic Acid is an isomer of benzenetricarboxylic acid with the chemical formula C9H6O6 . It is primarily used as carboxylate ligand in the synthesis of a wide range of metal-organic frameworks (MOFs).

Trimellitic anhydride , Trimellitic Acid can be separated, retained, and analyzed on a mixed-mode Newcrom B column with a mobile phase consisting of water, Acetonitrile (MeCN), and Formic acid (FA). This analytical method can be UV detected at 250 nm or via negatively-charged Electrospray Ionization (ESI-) with high resolution and peak symmetry.