HPLC Separation of Sodium, Potassium Ions and Tetramethylammonium Chloride on Newcrom AH Column
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Description
High Performance Liquid Chromatography (HPLC) Method for Analysis of Tetramethylammonium , Sodium , Potassium .
Tetramethylammonium chloride is a quaternary ammonium salt used widely as a reagent in industrial applications. It can be separated from sodium and potassium chlorides on a mixed-mode Newcrom AH column with a simple isocratic MS-compatible mobile phase of water, acetonitrile (ACN) and ammonium formate (AmFm) buffer.
Method Parameters
| Mobile Phase | MeCN/H2O – 50/50% |
|---|---|
| Buffer | AmFm pH 3.0- 10 mM |
| Flow Rate | 1.0 ml/min |
| Detection | CAD (Corona) MS- compatible mobile phase |
| Class of Compounds | Hydrophilic, Metal, Ion, Quaternary ammonium salt |
| Analyzing Compounds | Tetramethylammonium,Sodium,Potassium |
HPLC Column Used
Newcrom AH, 4.6 x 150 mm, 5 µm, 100 A, dual ended