ELSD HPLC Method for Analysis of Triflic acid on Primesep B Column
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Description
· High Performance Liquid Chromatography (HPLC) Method for Analysis of Triflic acid · Triflic acid, also known as trifluoromethanesulfonic acid, is a superacid with the chemical formula: · CF₃SO₃H
Triflic acid can be retained and analyzed using the Primesep B mixed mode column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile and ammonium formate. Detection is performed using ELSD.
Method Parameters
| Mobile Phase | MeCN/H2O – 70/30% |
|---|---|
| Buffer | Ammonium Formate pH 3.0 – 40 mM |
| Flow Rate | 1.0 ml/min |
| Detection | ELSD, the nebulizer and evaporator temperatures 40°C,with a gas flow rate of 1.6 Standard Liters per Minute (SLM) |
| LOD | 200 ppb |
| Class of Compounds | Acid |
| Analyzing Compounds | Triflic acid |
HPLC Column Used
Primesep B, 4.6 x 150 mm, 5 µm, 100 A, dual ended