HPLC Method for Analysis of 2-Chlorobenzyl Chloride and 4-Chlorobenzyl Chloride on Newcrom R1 Column
https://sielc.com/hplc-ms-method-2-chlorobenzyl-chlorideChromatogram
Description
High Performance Liquid Chromatography (HPLC) Method for Analysis of 2-Chlorobenzyl chloride , 4-Chlorobenzyl chloride
2-Chlorobenzyl Chloride Pharmaceutical intermediate – used to build drugs with chlorinated aromatic structures.
Agrochemicals – precursor for pesticides and herbicides. · Organic synthesis – for introducing a 2-chlorobenzyl group via nucleophilic substitution. · Dyes and pigments – used in manufacturing colorants.
4-Chlorobenzyl Chloride Pharmaceuticals – key building block for antihistamines, antidepressants, etc.
Polymer chemistry – used to modify or crosslink polymers.
Method Parameters
| Mobile Phase | MeCN -45% |
|---|---|
| Buffer | H3PO4 – 0.1% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 210 nm |
| LOD | 6.8 ppb, 9.9 ppb |
| Class of Compounds | Organic Halides (Alkyl Halides / Arylalkyl Halides) |
| Analyzing Compounds | 2-Chlorobenzyl chloride,4-Chlorobenzyl chloride |
HPLC Column Used
Newcrom R1, 3.2 x 100 mm, 5 µm, 100 A, dual ended