HPLC Method for Analysis of Venlafaxine on Primesep 100 Column

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Chromatogram

Description

· High Performance Liquid Chromatography (HPLC) Method for Analysis of Venlafaxine · Venlafaxine is an organic compound with the molecular formula C 17 H 27 NO 2 . · Properties: Appearance: Typically a white to off-white crystalline solid. · Molecular weight: ~277.4 g/mol · Solubility: Soluble in organic solvents.

Uses: A type of antidepressant. It is believed to work by increasing levels of serotonin and norepinephrine in the brain.

Venlafaxine can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and sulfuric acid. Detection is performed using UV at 200 nm.

Method Parameters

Mobile PhaseMeCN – 80%
BufferH2SO4 – 0.1%
DetectionUV 200 nm
Class of CompoundsDrug
Analyzing CompoundsVenlafaxine

HPLC Column Used

Primesep 100, 4.6 x 150 mm, 5 µm, 100 A, dual ended
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