HPLC Method for Analysis of Molnupiravir on Newcrom R1 Column
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Description
High Performance Liquid Chromatography (HPLC) Method for Analysis of Molnupiravir (EIDD-2801, MK-4482) .
Molnupiravir is an antiviral drug with the chemical formula C 13 H 19 N 3 O 7 . It works through inhibiting RNA replication in viruses like influenza and ebola. It gained recent notoriety in its ability to help treat COVID-19 infections from the SARS-CoV-2 virus. You can find detailed UV spectra of Molnupiravir (EIDD-2801, MK-4482) and information about its various lambda maxima by visiting the following link.
Molnupiravir (EIDD-2801, MK-4482) can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN). Detection is performed using UV. This analysis method can be UV detected at 235 nm with high resolution and peak symmetry.
Method Parameters
| Mobile Phase | MeCN -15% |
|---|---|
| Buffer | No |
| Flow Rate | 0.5 ml/min |
| Detection | UV 235nm |
| Class of Compounds | Drug |
| Analyzing Compounds | Molnupiravir (EIDD-2801, MK-4482) |