
· High Performance Liquid Chromatography (HPLC) Method for Analysis of 2,3-Dichlorobenzoic anhydride .
2,3-Dichlorobenzoic Anhydride is an impurity with the chemical formula C 14 H 6 Cl 4 O 3 . It is formed during the production of Lamotrigine, anticonvulsant used to treat epileptic seizures and Bipolar Disorder. Removing 2,3-Dichlorobenzoic Anhydride is paramount for maximizing Lamotrigine purity. It had no known uses outside of quality control. You can find detailed UV spectra of 2,3-Dichlorobenzoic anhydride and information about its various lambda maxima by visiting the following link.
2,3-Dichlorobenzoic anhydride can be retained and analyzed using the Primesep S2 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of acetonitrile (MeCN). Detection is performed using UV.
| Mobile Phase | MeCN- 100% |
|---|---|
| Buffer | No |
| Flow Rate | 1.0 ml/min |
| Detection | UV 210 nm |
| Class of Compounds | Anhydride |
| Analyzing Compounds | 2,3-Dichlorobenzoic anhydride |