ELSD HPLC Method for Analysis of Methanesulfonic acid on Primesep B Column
https://sielc.com/hplc-method-for-analysis-methanesulfonic-acidChromatogram
Description
· HPLC Method for Analysis of Methanesulfonic Acid on Primesep B Column by SIELC Technologies
Methanesulfonic acid (MSA) is an organosulfur compound with the chemical formula CH₄O₃S or structurally CH₃SO₃H. It is the simplest alkane sulfonic acid, consisting of a methyl group Applications: Catalysis: Used as a strong acid catalyst in organic and industrial chemical reactions, including esterifications and polymerizations. Electroplating: An electrolyte component in electroplating baths, especially for tin and tin-lead plating. Cleaning: Employed in industrial cleaning due to its strong acidity and non-oxidizing nature. Pharmaceuticals: Used in the preparation of certain drugs, intermediates, and active pharmaceutical ingredients. Alternative to Sulfuric Acid: Often preferred in specific applications because it is non-volatile and less corrosive to metals.
Methanesulfonic Acid can be retained, and analyzed using a Primesep B mixed-mode stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water, acetonitrile (MeCN), and phosphoric acid as a buffer. Detection is carried out using UV.
Method Parameters
| Mobile Phase | MeCN 40% |
|---|---|
| Buffer | Ammonium Formate pH 3.0 – 40 mM |
| Flow Rate | 1 ml/min |
| Detection | ELSD, the nebulizer and evaporator temperatures 70°C,with a gas flow rate of 1.6 Standard Liters per Minute (SLM) |
| LOD* | 10 ppb |
| Class of Compounds | Acid |
| Analyzing Compounds | Methanesulfonic Acid |