HPLC Method for Determination of Hydroxyzine in Tablets on Primesep SB Column
https://sielc.com/hplc-determination-of-hydroxyzine-in-tabletsChromatogram
Description
HPLC Method for Analysis of Hydroxyzine , Hydroxyzine dihydrochloride on Primesep SB Column by SIELC Technologies
Hydroxyzine is an antihistamine medication that is used to treat various conditions.
Antihistamine: Hydroxyzine belongs to the class of drugs known as first-generation antihistamines. It works by blocking the effects of histamine, a natural substance in the body that is involved in allergic reactions.
Uses: Hydroxyzine is used to treat itching caused by allergies, as well as to relieve symptoms of allergic reactions such as hives. It is also used as a sedative to manage anxiety and tension.
Allergic Reactions: In the context of allergic reactions, hydroxyzine helps alleviate symptoms like itching, redness, and swelling by blocking histamine receptors.
Anxiolytic Properties: It has sedative and anxiolytic (anxiety-reducing) properties, and it is sometimes prescribed to manage anxiety and tension.
Forms: Hydroxyzine is available in various forms, including tablets, capsules, and oral solutions. It can also be administered by injection in certain medical situations.
Method Parameters
| Mobile Phase | MeCN/H2O – 20/80% |
|---|---|
| Buffer | H2SO4 – 0.1% |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 232 nm |
| Class of Compounds | Drug, Antihistamine, Base, Hydrophobic, Ionizable |
| Analyzing Compounds | Hydroxyzine,Hydroxyzine dihydrochloride |