HPLC Chiral Separation of Bisphenol A diglycidyl ether Enantiomers on Cyralis AM Column
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Description
· High Performance Liquid Chromatography (HPLC) Method for Analysis of Bisphenol A diglycidyl ether .
Bisphenol A diglycidyl ether (BADGE or DGRBA) is a liquid epoxy resin with the chemical formula C 21 H 24 O 4 . It is a key component of commercially available resins as well as other formulations. It reacts with a variety of compounds to create various resins. For example, if BADGE reacts with acrylic acid, it will produce vinyl ester resin.
This application describes a normal-phase chiral HPLC method for the separation of Bisphenol A diglycidyl ether enantiomers using SIELC’s Cyralis AM chiral column. Cyralis AM is an amylose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications.
Bisphenol A diglycidyl ether can be retained and analyzed using the Cyralis AM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane and Ethanol. Detection is performed using UV.
Method Parameters
| Mobile Phase | Hexane/Ethanol |
|---|---|
| Flow Rate | 1.0 mL/min |
| Detection | UV 210 nm |
| Resolution | 1-2: 1.87, 2-3: 2.13 |
| Class of Compounds | Resin |
| Analyzing Compounds | Bisphenol A diglycidyl ether |