HPLC Analysis of Valsartan
https://sielc.com/Application-HPLC-Analysis-of-ValsartanChromatogram
Description
Valsartan is a drug commonly used to treat high blood pressure and congestive heart failure. Legacy L1 was used to retain valsartan by reverse phase mechanism in this HPLC separation method. Legacy L1 uses embedded C18 groups on porous silica and is useful for many USP HPLC applications. Comparisons to Phenomenex columns are available by request. This simple HPLC method can be used in many pharmaceutical areas. For example, in batch production, impurity profiling, formulation and pharmacokinetics.
Method Parameters
| Mobile Phase | MeCN – 50% |
|---|---|
| Buffer | NaH2PO4 pH 2.5 – 20 mM |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 254 nm |
| Class of Compounds | Drug, Hydrophilic, Ionizable |
| Analyzing Compounds | Valsartan |
HPLC Column Used
Legacy L1, 4.6×250 mm, 5 µm, 100A